Furthermore, Th1-polarized cytokine environment rich in IL-8, IL-12, and IL-12 mRNA, TNF-α, and IFN-γ has been reported in the active inflammatory lesions of BD patients, such as skin, oral and genital mucosa, stomach, intestine, and eye [6, 22, 60–62]. This evidence concerns the gene IFNG and Behcet disease.