The expression rates of intrinsic STAT3 inhibitor PIAS3 were 52.6% (20/38) among noncancerous epithelial tissues but reduced to 16.0% (4/25; p<0.01) and 11.6% (5/43; p<0.01) in cervical adenocarcinoma and squamous carcinoma samples, respectively. The gene discussed is PIAS3; the disease is cervical adenocarcinoma.