SNCA and Parkinson disease: By contrast, parkinsonism may be associated with a variety of pathologies, including neurofibrillary tangles (such as in progressive supranuclear palsy, corticobasal ganglionic degeneration, or parkinsonism-dementia complex of Guam), to the predominant oligodendroglial alpha-synuclein pathology of multiple system atrophy, or predominant cortical Lewy pathology associated with dementia with Lewy bodies.