MAPT and tauopathy: These include neurofibrillary tangles and tufted astrocytes (4R-tauopathies, as inclusion of MAPT exon 10 leads to the production of tau protein with four microtubule-binding domains), Tar DNA-binding protein 43 and ubiquitin immune-positive aggregates, or simply nigral neuronal loss with gliosis [30-32].