Although the role of S84 phosphorylation in colon cancer is unclear, the phosphorylation mimic mutant of PPARγ1 (S84D) slightly derepressed PPARγ-mediated transrepression of β-catenin using the TOPflash reporter system [23], and further characterization with regard to the effect in transcriptional function is needed (Shogo Katsura, unpublished result). Here, PPARG is linked to malignant colon neoplasm.