IL1B and Behcet disease: Convincing evidence of IL1β role in BD derives from a trial of gevokizumab in patients with multiresistant uveitis [45] and from the successful experience with anakinra [12, 43, 44, 47, 48] and canakinumab [46, 49, 50], while the increasing number of published reports of BD patients treated with tocilizumab [51–56] and rituximab [58–60] demonstrates the complex heterogeneous biochemical scenery behind this syndrome.