IL1B and rheumatoid arthritis: Anakinra is a recombinant human IL-1 receptor antagonist that competes with IL-1α and IL-1β and thus inhibits the proinflammatory effects of both cytokines: it has been approved for use in rheumatoid arthritis (at a recommended dose of 100 mg/day subcutaneously) and has been used off-label for a broad spectrum of inflammatory conditions, bringing about a sustained disease remission [61, 63].