And our previous showed that HMGN2 significantly inhibits the growth of Tca8113 cells, adenoid cystic carcinoma cell-2 line (ACC-2), human lung adenocarcinoma epithelial cell line A549 and bladder cancer cell line T24, which acted by promoting apoptosis in vitro and in vivo[24,25]. This evidence concerns the gene HMGN2 and lung adenocarcinoma.