Positive expression of both PLAG1 and KPNA2 could predict prognosis of HCC patients after hepatectomy Furthermore, the positive PLAG1 expression is the only risk factor for recurrence free survival and overall survival by multivariate analyses of patients with positive KPNA2 expression, further indicating the clinical significance of PLAG1 interaction with KPNA2 and harbor great applicability to distinguish HCC patient to be closely monitored after hepatectomy. The gene discussed is KPNA2; the disease is hepatocellular carcinoma.