KPNA2 and adenoma: One of the prominent of the cargo proteins of KPNA2 is the transcriptional factor PLAG1, previous evidence has illustrated that pleomorphic adenoma gene 1 (PLAG1) could be identified to be associated with KPNA2 in vitro and proved that a predicted nuclear localization sequence (NLS) composed of short stretches of basic amino acids was essential for physical interaction of PLAG1 with KPNA2 [13].