The up-regulated TCs proteins belong to the following pathways: nicotinic acetylcholine receptor (2 proteins), inflammation mediated by chemokines (2 proteins), de novo purine biosynthesis (2 proteins), cytoskeletal regulation by Rho GTPase (2 proteins), TCA cycle (1 protein), Parkinson disease (1 protein), integrin signalling (1 protein) and blood coagulation (1 protein) - Figure3C. The gene discussed is TCOF1; the disease is Parkinson disease.