SHH and Langer mesomelic dysplasia: Previously published work showed that metastasis (defined by the presence of microscopic tumor cells in the CSF, radiographically detected LMD, or metastasis outside of the central nervous system) was significantly more common in Group 3 (46.5%) and Group 4 (29.7%) than in the WNT (17.9%) and SHH (19.1%) subgroups [28].