When we correlated M-stage with ARNT expression levels in tumor subgroups from the combined MAGIC and COG series, we found that among 20 patients with Group 4 tumors, there were more cases of spinal LMD (M3-stage) in tumors showing high ARNT expression (top quartile) than low expression (bottom quartile) (χ2P = 0.02) (Figure 5C). This evidence concerns the gene ARNT and neoplasm.