We report for the first time a large cohort of foetuses with various malformations of cortical development due to mutations in 3 different tubulin genes (TUBA1A, TUBB2B and TUBB3), underlining the relatively high frequency of tubulinopathies among the causes of severe complex cortical malformations ranging from polymicrogyria-like cortical dysplasia to microlissencephaly with corpus callosum agenesis and ponto-cerebellar hypoplasia. This evidence concerns the gene TUBB2B and tubulinopathy.