In contrast, a higher number of cytotoxic CD8+ T cells (29.2 versus 20.7, p = 0,46) and perforine positive cells (6.5 versus 4.6, p = 0,46) was observed in ACD reactions as compared to psoriasis plaques (Fig. 3). The gene discussed is PRF1; the disease is granular corneal dystrophy type II.