PVT1 and colorectal carcinoma: High expression of PVT-1 expression in cancerous tissues was regarded as an independent risk factor for overall survival of CRC patients [12], and HOTAIR, functioning as an oncogene or a tumor suppressor, was implicated in epigenetic regulation for cancers [7], [13], which was considered as a strong prognosis maker that contributed to predict metastasis and patients’ survival in primary breast cancer [7].