To analyze the role of c-Jun in the stability of HIF-1α protein enhanced by HPV-16 oncoproteins, HPV-16-transfected NSCLC cells were co-transfected with c-Jun siRNA (Si-1 or Si-2) or nonspecific (NS)-siRNA, followed by treatment with 10 μg/mL CHX. This evidence concerns the gene HIF1A and non-small cell lung carcinoma.