JUN and non-small cell lung carcinoma: Our results showed that when c-Jun was inhibited by its specific siRNA, the increase of HIF-1α, VEGF, and IL-8 protein expression (Figure 5D and E) induced by HPV-16 oncoproteins in NSCLC cells was also blocked (Figure 5D and E), suggesting that HIF-1α, VEGF, and IL-8 protein expression induced by HPV-16 oncoproteins was c-Jun-dependent.