HIF1A and non-small cell lung carcinoma: However, our previous and present results showed that over-expression of HPV-16 E6 and E7 had no effect on HIF-1α mRNA expression in NSCLC cells [26], indicating that HPV-16 oncoproteins enhanced HIF-1α protein accumulation via a post-transcriptional mechanism, e.g. affecting HIF-1α protein stability.