Moreover, we further found that HPV-16 E6 and E7 oncoproteins decreased ubiquitinated HIF-1α levels in NSCLC cells (Figure 4C), suggesting that HPV-16 oncoproteins inhibited HIF-1α degradation is possibly, at least in part, through interfering with 26S proteasome degradation pathway, thus triggering HIF-1α protein accumulation in NSCLC cells. This evidence concerns the gene HIF1A and non-small cell lung carcinoma.