Our results showed that the increased HIF-1α protein stability induced by HPV-16 oncoprotein was abrogated by c-Jun siRNA (Si-1 or Si-2) co-transfection, but not by NS-siRNA co-transfection (Figure 7A, B), indicating that HPV-16 oncoproteins enhanced HIF-1α protein stability in NSCLC cells was c-Jun-dependent. The gene discussed is JUN; the disease is non-small cell lung carcinoma.