In this study, we investigated the roles of PI3K/Akt and JNK/c-Jun signaling pathways in HIF-1α, VEGF, and IL-8 expression, and invitro angiogenesis induced by HPV-16 E6 and E7 oncoproteins in NSCLC cells. This evidence concerns the gene MAPK8 and non-small cell lung carcinoma.