MAPK8 and non-small cell lung carcinoma: However, the decease of p-c-Jun levels by SP600125, a specific JNK inhibitor, had no obvious effects on HIF-1α protein expression in HPV-16-transfected NSCLC cells (Figure 5B and C), suggesting HIF-1α protein accumulation induced by HPV-16 oncoproteins was JNK/c-Jun-independent in NSCLC cells.