Data from articles published about this topic show a PPV of 14%–75% and NPV of 84%–98%.6,17,21,26 In a recent study in Brazil, patients with eosinophilia and IgE increase had relative risks for helminthiasis of 11 and 8, respectively.34 These results show the relative high value of eosinophilia and IgE as biomarkers for helminthiasis in patients from tropical and subtropical areas. The gene discussed is IGHE; the disease is helminthiasis.