We found that higher expression of HBEGF is correlated with 34% of 15-year survival rate (Figure 6B), and that the neighbors of HBEGF in the HBEGF subnetwork are involved in diverse biological processes and functions, such as glycolysis, apoptosis, participating in laminin-5 complex, notch signaling pathway, and angiogenesis, all of which are in line with previous findings showing the high expression level of HBEGF is positively related to the aggressiveness of the breast tumors [43] and that HBEGF plays key roles in tumorigenicity and invasiveness of ovarian cancer [44]. This evidence concerns the gene HBEGF and breast neoplasm.