Finally, in order to identify potential novel drug targets, we also investigated hubs (i.e., genes with high degrees, see details in Materials and Methods) in the differential networks of the breast cells, and characterized specifically three hubs (NEBL, HBEGF, and PAPD7) whose aberrant expression values are linked with the worst survival outcomes in the breast cancer patients to provide insight into their functional significance on the growth and development of breast cancer cells. The gene discussed is HBEGF; the disease is breast cancer.