To determine the potential of XPO1 as a molecular target in melanoma cells, XPO1 protein expression was characterized in a human melanoma tissue microarray (nevi, primary melanomas, and metastatic melanomas), a panel of human metastatic melanoma cell lines (A375, Hs294T, FO-1, Wm1366, CHL-1) or three primary human epidermal melanocyte cell lines (HEM-l, HEMn-MP, HEMn-DP). Here, XPO1 is linked to metastatic melanoma.