RAF1 and Noonan syndrome with multiple lentigines: For instance, mutations in the 14-3-3-binding motif of Raf1 abrogate its interaction with 14-3-3 proteins in Noonan and Leopard syndromes.48 Although examples exist of diseases caused by the known loss of protein–protein interactions due to mutations in the SLiMs, we wanted to observe whether there is a trend at a proteome-wide scale such that the more interactions a SLiM mediates, the higher is its likelihood to be associated to disease.