Notably, mice deficient in NFATC2 showed hyperproliferation of lymphocytes, accompanied by a reduction in cell death and an increased cell cycle rate [64], [68]–[71], whereas NFATC2-/NFATC3- double knock-out mice developed lymphoproliferative disorder with marked lymphadenopathy and splenomegaly, decreased activation-induced death and impaired Fas ligand induction [72]. This evidence concerns the gene NFATC2 and lymphoproliferative syndrome.