CD4 and autoimmune thrombocytopenic purpura: Quite contrary to increased number of IL-10+CD19+ B cells, the percentage of CD4+CD25highFOXP3+ Tregs was significantly decreased in newly-diagnosed ITP patients when compared with that in normal controls ((2.87 ± 1.22)% versus (6.17 ± 1.67)%; P < 0.001) (Figures 2(a) and 2(b)).