Two other proteins proposed as biomarkers in PI were also identified: neutrophil collagenase/MMP-8 (P22894) upregulated 1.1x in AP, 1.82x in CP, and 9.7x in PI and neutrophil elastase (P08246) upregulated 2x in AP, 6.5x in CP, and 12.8x in PI. The gene discussed is MMP8; the disease is alkaline phosphatase measurement.