In addition to Ph chromosome, blast phase transformation of CML is usually accompanied by additional chromosomal abnormalities, such as +8, +Ph, i(17q), +19, −Y, +21, +17, or monosomy 7, suggesting that CML-BP is the evolution of a BCR/ABL1-positive clone [1, 2]. The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.