Mutations of both the cytoplasmic (IDH1) and the mitochondrial (IDH2) NADPH-dependent isoforms have been found in various human cancers, including colon cancer[22], glioblastoma[23], glioma[24], acute myeloid leukemia[25], prostate cancer[26], B-acute lymphoblastic leukemia[26], osteosarcoma[27], and intrahepatic cholangiocarcinoma[28]. The gene discussed is IDH2; the disease is cancer.