HR is not deleted for GTF2I or other more telomeric genes, but her deletion does include a reduced expression of (and thus haploinsufficiency for) GTF2IRD1. Given HR’s difficulties in mentally rotating objects, these results support previous findings that haploinsufficiency for GTF2IRD1 in combination with other 7q11.23 genes such as CYLN2 or LIMK1 may play a role in some of the (small-scale) visuospatial cognitive deficits observed in individuals with WS [14,58]. Here, CLIP2 is linked to Werner syndrome.