HMGB1 and Sepsis: To evaluate the effect of EA at ST36 on serum TNF, IL-6, nitrite, and HMGB1 levels during sepsis, four groups of rats were formed: one group underwent surgery without CLP (SHAM), and three groups were subjected to CLP, where one of these groups was treated with EA at ST36 (CLP+ST36) or sham acupuncture (CLP+SHAM-EA) after closure and suturing of the abdominal cavity.