In the present study, we aim to examine the potential protective effect of fenugreek on kidney in the streptozotocin- (STZ-) induced diabetic rats and further to confirm whether fenugreek could reduce DN risk through alleviating renal oxidative stress and inhibiting TGF-β1/CTGF signaling pathway in glomeruli of the STZ-induced diabetic rats. The gene discussed is CCN2; the disease is liver dysplastic nodule.