MECP2 and systemic lupus erythematosus: However, microarray analyses of neural tissue from Mecp2-deficient mice have consistently included immune genes, e.g., Irak-1 [58], as among the most highly aberrant in transcription as a result of loss of Mecp2. Along these lines, MeCP2 was recently named as a candidate susceptibility gene for systemic lupus erythematosus, an autoimmune disorder [124].