APP and neoplasm: Disruption of the interactions of IL-10 with its receptors (IL-10RA and IL-10RB) and α-2-macroglobulin (A2M) may lead to enhanced inflammation, which could promote tumor growth; blockage of the A2M-APP interaction may lead to cancerous cellular proliferation through free APP; blockage of A2M-KLK13 (hK13) interaction can increase free hK13, which can promote cancer cell growth, metastasis and invasion through damage in the extracellular matrix.