With reference to RCC etiopathogenesis, historically, among the most frequent chromosomal alterations involved in its onset are those that lead to the functional inactivation (due to the loss of both alleles) of the von Hippel-Lindau protein (pVHL), the product of the VHL tumor suppressor gene that is located on chromosomal region 3 p25–26 [4]. This evidence concerns the gene VHL and renal cell carcinoma.