Yamazaki et al. emphasized the observed strong c-KitR over-expression in chromophobe variety of RCC with the purpose to clarify the nature of its tumorigenesis, considering that no gene mutations have been noted related to the development of chromophobe variety compared to the well known VHL and mesenchymal-epidermal transition (MET) genetic mutations involved in the tumorigenesis of clear cell and papillary RCCs, respectively [31]. The gene discussed is VHL; the disease is renal cell carcinoma.