The transfer of splenocytes from the autoimmune-prone NOD mouse after immunisation with recombinant murine PR3 (rmPR3) generated a necrotising glomerulonephritis in immunodeficient NOD-SCID recipients but this was not seen after similar transfer of splenocytes from rmPR3-immunised C57BL/6 control mice, implicating the autoimmune-prone background as a critical factor in expression of a disease phenotype [97]. Here, PRTN3 is linked to glomerulonephritis.