Kain et al. showed that circulating anti-LAMP2 antibodies were present in 78/84 AAV patients with active glomerulonephritis irrespective of other ANCA specificities (84 IF ANCA+, 38 MPO+, 39 PR3+) and that autoantibody levels fell with recovery. The gene discussed is PRTN3; the disease is anti-neutrophil cytoplasmic antibody-associated vasculitis.