Adoptive transfer of anti-MPO antibodies can induce a crescentic glomerulonephritis in recipient mice [94] but disease is prevented if recipient mice are deficient in components of the alternative (C5, factor B) but not classical (C4) complement pathway [100] and can be treated (in mice) by blocking the terminal complement component C5 [101]. The gene discussed is MPO; the disease is glomerulonephritis.