Furthermore, while LAMP2 showed no homology with MPO or PR3 (thus excluding synergy with the anti-idiotype hypothesis), it showed significant similarity to the sequence of the bacterial protein FimH, which could induce both LAMP2-IgG and a pauci-immune glomerulonephritis on immunisation of WKY rats. The gene discussed is PRTN3; the disease is glomerulonephritis.