Taken together, the complementary data revealed that (i) O/Tibet/CHA/6/99wt, O/Fujian/CHA/9/99wt, rHN/TAR6-VP1, rHN/FJ9-VP1K1083E and rHN/TAR6-VP1E1083K utilize an integrin-mediated pathway for viral infection in BHK-21 cells; (ii) O/Fujian/CHA/9/99tc and rHN/TAR6-VP0 can completely dispense with their RGD integrin-binding site and utilize heparin-sensitive receptor(s) to infect BHK-21 cells; and (iii) efficient infection with rHN/FJ9-VP1 should be mediated by the presence of integrins and heparin-sensitive receptors on the surface of BHK-21 cells. The gene discussed is TAAR6; the disease is viral infectious disease.