Consistent with our results obtained with NSCLC cells [12], we found that inhibition of MET signaling by either of these agents resulted in induction of apoptosis associated with inhibition of AKT and ERK phosphorylation in gastric cancer cells with MET amplification but not in those without it, suggesting that MET signaling is essential for the survival of MET amplification-positive cells. The gene discussed is AKT1; the disease is gastric cancer.