We found that inhibition of MET signaling with crizotinib or MET siRNA induced apoptosis that was accompanied by attenuation of the phosphorylation (activation) of AKT and the MAPK extracellular signal-regulated kinase (ERK) in NSCLC cells with MET amplification but not in those positive for a non-kinase domain mutation (N375S or deletion of exon 14) of MET [12]. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.