Our recent GBM secretome study also revealed that IL-1 upregulates secretory molecules implicated in glioma progression such as MMP2, tenascin-C, galectin-1, pentraxin 3, IL-8 and MCP-1, while (down)modulating numerous extracellular matrix (ECM) and ECM-modulating proteins [14]. This evidence concerns the gene IL1A and central nervous system cancer.