Subsequent analysis using GSEA demonstrated that the genes obtained by mining these relationships were biologically meaningful and had overlap with several known cancer genes -TP53, PTEN, RB1 in glioblastoma; MYC, EZH2, CCND1, E-cadherin in ovarian cancer, as well as overlap with genes in important signaling pathways - MTOR in glioblastoma and WNT in ovarian cancer. This evidence concerns the gene RB1 and glioblastoma.