Mutations involving members of the IL-6 receptor gene family like OSMRß and IL-31RA results in dysfunction of the downstream signals like Jak/STAT, Erk1/2, and PI3K/Akt with antiapoptotic effects in several tumor cell lines and this might also be the reason of keratinocyte apoptosis in PLCA [16, 17]. This evidence concerns the gene IL31RA and neoplasm.