Taken together with our previous observations that LPA-stimulated migration of ovarian cancer cells require Gα13-regulated Rac-activation [34, 46] and activated Gα13 promotes the formation of a Hax-1-Rac1-cortactin signaling complex [5], the present observation that Hax-1 is required for Rac1-Cortactin interaction establish a critical role for Hax-1 in scaffolding the interaction between Rac1 and cortactin (Fig. 8). The gene discussed is HAX1; the disease is ovarian carcinoma.