The increased expression of YY1 was reported in prostate cancer [38-41], colon cancer [39,42], ovary cancer [39,40], breast cancer [42,43], skin cancer [40,43], cervix cancer [40,44], bladder cancer [39,40], bone cancer [45], liver cancer [39], and lung cancer [39]. The gene discussed is YY1; the disease is Familial prostate cancer.