There was a weak positive correlation between serum phosphate and sclerostin in the entire cohort (β = 0.153, P = 0.059), which did not persist when different CKD groups (β = 0.128, P = 0.474 for CKD-G1/2 group, β = 0.066, P = 0.517 for CKD-G3~5 group) were analyzed separately in the multiple regression analysis. The gene discussed is SOST; the disease is chronic kidney disease.