Moreover, the C-terminal region of LARP7, which is essential for the sequestration of P-TEFb in 7SK snRNP, is required for LARP7's suppression of breast cancer survival and is frequently deleted in human gastric cancer (Mori et al., 2002), suggesting that LARP7 may be a potential tumor suppressor in a broad range of human carcinomas. This evidence concerns the gene LARP7 and neoplasm.