LCHa cases are related to mutations in PAFAH1B1 or DCX, whereas LCHb cases are linked to a mutation in RELN. Based on the LCH pattern of the patient presenting microcephaly (≤ - 3 SD), this case may be classified as LCHd, which could be related to a mutation in TUBA1A. Therefore, no contradiction in the etiology of the TUBA1A mutation was observed. This evidence concerns the gene PAFAH1B1 and microcephaly.