Higher IGF-1 expression in non-neoplastic liver was associated with significantly poorer median survival of 22 months (95% confidence interval, 0 to 54 months), compared with 72 months (95% confidence interval, 37 to 107 months) with equal or lower IGF-1 expression in adjacent liver relative to tumor (P = 0.006, Figure 3). Here, IGF1 is linked to neoplasm.