While no gene was located in all three pathways we detected 4 genes common between “axon guidance” and “calcium signaling” (PPP3R1, CHP2, PPP3CA, PPP3CC), 6 genes in common between “calcium signaling” and “focal adhesion” (PRKCB, PDGFRA, PRKCA, MYLK4, MYLK, EGFR) as well as 11 genes in common between “axon guidance” and “focal adhesion” (PAK1, GSK3B, PAK6, ITGB1, PAK7, FYN, CDC42, ROCK1, ROCK2, MAPK1, PTK2), representing likely key-players for DCM. This evidence concerns the gene ITGB1 and familial dilated cardiomyopathy.