Compared to wildtype controls, cpe−/− mice displayed a higher histology score comprised from the degree of mucosal edema, abscesses and ulcer as well as the numbers of infiltrating immune cells (4.07±1.66 (cpe−/−) vs. 2.77±1.17 (cpe+/+), p<0.05) (Figure 2D, E). This evidence concerns the gene CPE and ulcer disease.