Bioavailability and antitumor effects of SapC-DOPS in human glioblastoma mouse models. We previously reported the antiangiogenic and pro-survival effects of SapC-DOPS on different mouse GBM models, including one that expressed EGFRvIII, a constitutively active EGFR representing the most common mutation found in EGFR-amplified GBMs [11]. This evidence concerns the gene EGFR and glioblastoma.