For instance, several loss-of-function of tumor suppressors, such as tp53 [18], PTEN [19] and APC [20], or gain-of-function of oncogenes, c-myc [21], Akt2 [22], and K-ras [23], have been established in zebrafish, which showed similar phenotypes to human cancer. The gene discussed is TP53; the disease is neoplasm.