The enhanced directional migration of macrophages towards hypoxic tumor cells and their polarization to M2-like macrophages was attributable to hypoxic tumor cell derived Eotaxin and Oncostatin M. Hypoxic tumor cells exhibited upregulated intracellular levels of Eotaxin and Oncostatin M, which in turn was accompanied by their enhanced release in the culture supernatant. This evidence concerns the gene CCL11 and neoplasm.