In contrast, many other studies found higher serum adiponectin levels or a higher adiponectin/leptin ratio in pancreatic cancer patients who exhibited a positive or strong positive expression of AdipoR1 and AdipoR2 and that this higher level correlated strongly with the proinflammatory cytokine IL-6 [2, 12-14]. This evidence concerns the gene ADIPOR1 and familial pancreatic carcinoma.