No significant correlation was found in the others markers tested (expression of CD38, p53 deletion and ATM deletion), Furthermore we did not detect in our cohort of CLL patients a significant association of high p27 with Rai staging (P = 0.88, n = 85), progression of the leukemia (P = 0.69, n = 86) and with overall survival (P = 0.4, n = 86) (not shown). This evidence concerns the gene TP53 and B-cell chronic lymphocytic leukemia.