In this study, we have demonstrated for the first time the alterations of histone acetylation H3 in the PS1 and BACE1 promoter regions by utilizing an in vitro model of a murine neuroblastoma cell line in which Aβ deposits are induced by transfection with Swedish human APP695 (N2a/APPswe) [15], and we have also established the critical role of p300 in the regulation of histone acetylation in PS1 and BACE1 by using curcumin, a natural selective inhibitor of p300 in HATs [16], [17]. The gene discussed is EP300; the disease is neuroblastoma.