In addition, we incubated blast cells from AML-M2, ALL-L2 (acute lymphoblastic leukemia) patients and healthy donors with increasing concentration of FTY720, and observed a dose-dependent increase in the percentage of the cells that underwent apoptosis identified as annexin V+ and/or 7AAD+ cells by flow cytometry (Fig. 1C). Here, ANXA5 is linked to acute myeloid leukemia.