However, as a multi-target drug, it's difficultto rule out the ability of FTY720 inhibition to SPHK1 contributes to its cytotoxicity on Kasumi-1 cells, because reducing the cellular level of anti-apoptotic S1P could further sensitize tumor cells to FTY720 and ceramide induced apoptosis [47]. The gene discussed is SPHK1; the disease is neoplasm.