In response to silica, the processing and secretion of the pro-inflammatory cytokine Interleukin-1 β (IL-1β) in a caspase-1/ NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome-dependent manner initiates a cascade of innate immune responses leading to neutrophilic inflammation and granulomas [9]–[13]. Here, IL1B is linked to Granuloma.